期刊
MAGNETIC RESONANCE IMAGING
卷 25, 期 6, 页码 754-759出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2007.03.014
关键词
fMRI; electrical stimulation; primary visual cortex; Macaca mulatta; neuroprosthesis
Electrical microstimulation via intracortical electrodes is a widely used method for deducing functions of the brain. In this study, we compared the spatial extent and amplitude of BOLD responses evoked by intracortical electrical stimulation in primary visual cortex with BOLD activations evoked by visual stimulation. The experiments were performed in anesthetized rhesus monkeys. Visual stimulation yielded activities larger than predicted from the well-established visual magnification factor. However, electrical microstimulation yielded an even greater spread of the BOLD response. Our results confirm that the effects of electrical microstimulation extend beyond the brain region expected to be excited by direct current spread. (c) 2007 Elsevier Inc. All rights reserved.
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