期刊
NEUROBIOLOGY OF AGING
卷 28, 期 7, 页码 1112-1123出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2006.05.021
关键词
presbycusis; cochlea; inferior colliculus; gene microarray; immunohistochemistry; otoacoustic emissions
资金
- NIA NIH HHS [P01 AG09524] Funding Source: Medline
- NIDCD NIH HHS [P30 DC05409] Funding Source: Medline
Serotonin (5-HT) is a monoamine neurotransmitter. Serotonin may modulate afferent fiber discharges in the cochlea, inferior colliculus (IC) and auditory cortex. Specific functions of serotonin are exerted upon its interaction with specific receptors; one of those receptors is the serotonin 2B receptor. The aim of this study was to investigate the differences in gene expression of serotonin 2B receptors with age in cochlea and IC, and the possible correlation between gene expression and functional hearing measurements in CBA/CaJ mice. Immunohistochemical examinations of protein expression of IC in mice of different age groups were also performed. Gene expression results showed that serotonin 2B receptor gene was upregulated with age in both cochlea and IC. A significant correlation between gene expression and functional hearing results was established. Immunohistochemical protein expression studies of IC showed more serotonin 2B receptor cells in old mice relative to young adult mice, particularly in the external nucleus. We conclude that serotonin 2B receptors may play a role in the pathogenesis of age-related hearing loss. (C) 2006 Elsevier Inc. All rights reserved.
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