期刊
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING
卷 24, 期 3, 页码 325-336出版社
BRAZILIAN SOC CHEMICAL ENG
DOI: 10.1590/S0104-66322007000300003
关键词
chitosan microspheres BSA lysozyme adsorption
Chitosan microspheres with a mean size of 140 119 pm were produced by the spray and coagulation methods. The microspheres were chemically modified using the following routes: a) crosslinking with glutaraldehyde b) crosslinking with epychlorohydrin and c) acetylation. For investigation of their ability as adsorbents, the following standard proteins were chosen as adsorbates: bovine serum albumin - BSA (pl = 4.8 and MW = 66 kDa) and lysozyme (pI = II and MW = 14 kDa). The adsorption experiments were performed using a static method. The adsorption media and equilibrium concentration of adsorbates were varied in the ranges of pH 4-11 and 0.07-0.70 mg.ml(-1), respectively. The maximum adsorption capacities (q(m)) and the constant of the Langmuir model (K-s) were shown to be dependent on charge interactions and on the kind of treatment performed on chitosan rnicrospheres. The satisfactory fit of a kinetic model to the experimental data shows that the step that controls the adsorption kinetics is probably the initial adsorbate transport.
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