期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 13, 页码 3599-3602出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.04.054
关键词
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Artemisinin was reduced to dihydroartemisinin and coupled to a carboxylic acid derivative of quinine via an ester linkage. This novel hybrid molecule had potent activity against the 3D7 and (drug-resistant) FcB1 strains of Plasmodium falciparum? in culture. The activity was superior to that of artemisinin alone, quinine alone, or a 1:1 mixture of artemisinin and quinine. (c) 2007 Elsevier Ltd. All rights reserved.
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