期刊
PEDIATRIC ANESTHESIA
卷 17, 期 7, 页码 684-687出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1460-9592.2006.02182.x
关键词
codeine; complications; apnea; genetic polymorphism; pediatrics; obstructive sleep apnea
We present a case of a 29 months old previously healthy child who experienced apnea resulting in brain injury following a dose of acetaminophen and codeine 2 days after an uneventful anesthetic for tonsillectomy. A genetic polymorphism leading to ultra-rapid metabolism of codeine into morphine resulted in narcosis and apnea. This paper discusses the use of codeine for pain relief, obstructive sleep apnea, the alteration of the CYP2D6 gene and the resulting effect on drug metabolism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据