期刊
NEUROBIOLOGY OF AGING
卷 28, 期 7, 页码 1051-1061出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2006.05.026
关键词
posterior cortical atrophy; Alzheimer's disease; voxel-based morphometry; magnetic resonance imaging; magnetic resonance spectroscopy
资金
- NIA NIH HHS [U01 AG006786, P50 AG016574-090004, P50 AG16574, U01 AG006786-23, P50 AG016574, U01 AG06786, R01 AG011378, R01 AG11378, R01 AG011378-15] Funding Source: Medline
- NICHD NIH HHS [K12 HD049078, HD49078] Funding Source: Medline
The aim of this study was to compare patterns of cerebral atrophy on MRI, and neurochemistry on magnetic resonance spectroscopy (MRS), in patients with posterior cortical atrophy (PCA) and typical Alzheimer's disease (AD). Voxel-based morphometry was used to assess grey matter atrophy in 38 patients with PCA, 38 patients with typical AD, and 38 controls. Clinical data was assessed in all PCA patients. Single voxel H-1 MRS located in the posterior cingulate was analyzed in a subset of patients with PCA, typical AD, and control subjects. PCA showed a pattern of atrophy affecting occipital, parietal and posterior temporal lobes, compared to controls. The pattern was bilateral, but more severe on the right. Patients with PCA showed greater atrophy in the right visual association cortex than patients with typical AD, whereas those with AD showed greater atrophy in the left hippocampus than those with PCA. H-1 MRS suggested loss of neuronal integrity and glial activation in subjects with PCA and typical AD. The differing patterns of' atrophy on MRI Suggest that PCA should be considered a distinct entity from typical AD. (C) 2006 Elsevier Inc. All rights reserved.
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