期刊
ANALYTICAL CHEMISTRY
卷 80, 期 22, 页码 8840-8844出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac801586r
关键词
-
资金
- NHLBI Proteomics Initiative [N01-HV-28181]
A gold coated nanoporous alumina surface was used for dual ionization mode mass spectrometric analysis using desorption electrospray ionization (DESI) and laser desorption ionization (LDI). DESI and LDI mass spectrometry (MS) from the nanoporous alumina surface were compared with conventional electrospray ionization (ESI) mass spectrometry and matrix assisted laser desorption ionization (MALDI) for analysis of tryptic digests of proteins. Combined use of DESI and LDI offer greater peptide coverage than either method alone and comparable peptide coverage as with dual MALDI and ESI. This dual ionization technique using a common platform with same sample spot demonstrates a potential time and cost-effective toot for improved shotgun proteomic analysis.
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