期刊
EXPERT OPINION ON PHARMACOTHERAPY
卷 8, 期 10, 页码 1433-1439出版社
INFORMA HEALTHCARE
DOI: 10.1517/14656566.8.10.1433
关键词
genetics; spastic paraplegia
Hereditary spastic paraplegia (HSP) comprises a group of clinically and genetically heterogeneous diseases that affect the upper motor neurons and their axonal projections. A total of 30 chromosomal loci have been identified for autosomal dominant, recessive and X-linked HSP. The underlying genes for 15 of these loci have been described. The molecular dissection of the cellular functions of the related gene products has already greatly advanced our understanding of the most critical pathways involved in HSP. It is hoped that in the foreseeable future this knowledge will begin to translate into novel pharmacological approaches for this devastating disease.
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