期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 104, 期 27, 页码 11376-11381出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0704145104
关键词
cloning; gene regulation; transformation; linkage disequilibrium
Flowering time is a fundamental trait of maize adaptation to different agricultural environments. Although a large body of information is available on the map position of quantitative trait loci for flowering time, little is known about the molecular basis of quantitative trait loci. Through positional cloning and association mapping, we resolved the major flowering-time quantitative trait locus, Vegetative to generative transition 1 (Vgt1), to an approximate to 2-kb noncoding region positioned 70 kb upstream of an Ap2-like transcription factor that we have shown to be involved in floweringtime control. Vgt1 functions as a cis-acting regulatory element as indicated by the correlation of the Vgtl alleles with the transcript expression levels of the downstream gene. Additionally, within Vgti, we identified evolutionarily conserved noncoding sequences across the maize-sorghum-rice lineages. Our results support the notion that changes in distant cis-acting regulatory regions are a key component of plant genetic adaptation throughout breeding and evolution.
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