期刊
SCIENCE
卷 317, 期 5834, 页码 130-132出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1142311
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资金
- NHLBI NIH HHS [R37 HL 32854-22, R01 HL 58398-08, R37 HL032854, R01 HL058398] Funding Source: Medline
The airway epithelium plays an essential role in innate immunity to lung pathogens. Ribonucleoprotein particles primarily composed of major vault protein (MVP) are highly expressed in cells that encounter xenobiotics. However, a clear biologic function for MVP is not established. We report here that MVP is rapidly recruited to lipid rafts when human lung epithelial cells are infected with Pseudomonas aeruginosa, and maximal recruitment is dependent on bacterial binding to the cystic fibrosis transmembrane conductance regulator. MVP was also essential for optimal epithelial cell internalization and clearance of P. aeruginosa. These results suggest that MVP makes a substantial contribution to epithelial cell-mediated resistance to infection.
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