期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 59, 期 6, 页码 427-443出版社
ELSEVIER
DOI: 10.1016/j.addr.2007.04.006
关键词
solid lipid nanoparticles; nanostructured lipid carriers; skin; topical use; active pharmaceutical ingredient (API); API-carrier interactions; drug-carrier interactions; topical glucocorticoids; benefit/risk ratio
Due to the lower risk of systemic side effects topical treatment of skin disease appears favourable, yet the stratum comeum counteracts the penetration of xenobiotics into viable skin. Particulate carrier systems may mean an option to improve dermal penetration. Since epidermal lipids are found in high amounts within the penetration barrier, lipid carriers attaching themselves to the skin surface and allowing lipid exchange between the outermost layers of the stratum comeum and the carrier appear promising. Besides liposomes, solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been studied intensively. Here we describe the potential of these carrier systems and compare the dermal uptake from SLN and NLC to the one of alternative vehicle systems. A special focus is upon the interactions of active ingredients and the lipid matrix as well as the quantification of dermal penetration. (c) 2007 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据