期刊
NEUROSCIENCE LETTERS
卷 422, 期 2, 页码 103-108出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2007.05.034
关键词
OMgp; Nogo receptor; CNS; regeneration
Oligodendrocyte myelin glycoprotein (OMgp) is one kind of myelin-derived inhibitor, which strongly inhibits axonal regeneration through binding to its receptor NgR after the injury to the adult central nervous system (CNS). However, expression of OMgp and NgR after the adult spinal cord injury (SCI) remains unclear. Study on these problems will help to understand more comprehensively about the functions of these proteins in CNS during regeneration. Here, by using immunohistochemistry and reverse transcriptase PCR (RT-PCR), we found that after SCI, both OMgp and NgR expressions were detected in neurons and oligodendrocytes with a similar change profile that increased immediately and decreased gradually. We also found that the expression of ONlgp is not limited in oligodendrocytes and its receptor NgR is not limited in neurons. They both can be expressed by these two kinds of cells. The roles of these factors in CNS regeneration require further study. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据