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The interferons: 50 years after their discovery, there is much more to learn

期刊

JOURNAL OF BIOLOGICAL CHEMISTRY
卷 282, 期 28, 页码 20047-20051

出版社

AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R700004200

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资金

  1. NCI NIH HHS [R01 CA 46465] Funding Source: Medline
  2. NIAID NIH HHS [R01 AI 36450, R01 AI 43369] Funding Source: Medline

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The interferons (IFNs) and their receptors represent a subset of the class 2 alpha-helical cytokines that have been in chordates for millions of years. This brief review focuses on the discovery and purification of interferons, cloning of human IFN-alpha and IFN-beta, interferon receptors, activities and therapeutic uses of interferons, and the side effects of interferons.

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