期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 14, 页码 3877-3879出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.04.106
关键词
DPP-4; molecular modeling; potency; selectivity against DPP-8/9
Molecular modeling was used to improve potency of the cyclohexylamine series. In addition, a 3-D QSAR method was used to gain insight for reducing off-target DPP-8/9 activities. Compounds 3, 4, and 5 were synthesized and found to be potent DPP4 inhibitors, in particular 4 and 5 are designed to be highly selective against off-target DASH enzymes while maintaining potency on DPP-4. (C) 2007 Elsevier Ltd. All rights reserved.
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