期刊
ANALYTICAL BIOCHEMISTRY
卷 417, 期 1, 页码 1-16出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2011.05.027
关键词
Gold nanoparticle; Amplification; Recognition; Biosensing
资金
- National Natural Science Foundation of China [21035002, 20875013]
- Natural Science Foundation of Jiangsu Province [BK2010059]
- Technology Support Program of Jiangsu Province [SBE200900289]
- State Key Laboratory of Bioelectronics, Southeast University
Colloidal gold nanoparticles (AuNPs), with unique properties such as highly resonant particle plasmons, direct visualization of single nanoclusters by scattering of light, catalytic size enhancement by silver deposition, conductivity, and electrochemical properties, are very attractive materials for several applications in biotechnology. Furthermore, as excellent biological tags, AuNPs can be easily conjugated with biomolecules and retain the biochemical activity of the tagged biomolecules, making AuNPs ideal transducers for several biorecognition applications. The goal of this article is to review recent advances of using AuNPs as labels for signal amplification in biosensing applications. We focus on the signal amplification strategies of AuNPs in biosensing/biorecognition, more specifically, on the main optical and electrochemical detection methods that involve AuNP-based biosensing. Particular attention is given to recent advances and trends in sensing applications. (C) 2011 Elsevier Inc. All rights reserved.
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