期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 14, 页码 3910-3915出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.04.102
关键词
gamma-secretase; benzoazepinone; inhibitors
We report the synthesis of benzoazepine-derived cyclic malonamides (2) and aminoamides (3) as gamma-secretase inhibitors for the potential treatment of Alzheimer's disease. The in vitro structure-activity relationships of 2 and 3 along with dog pharmacokinetic results are described. (C) 2007 Elsevier Ltd. All rights reserved.
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