期刊
JOURNAL OF CELL SCIENCE
卷 120, 期 14, 页码 2378-2389出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.009654
关键词
trans-Golgi network; endosomes; CIMPR; protein sorting
类别
资金
- MRC [G117/452] Funding Source: UKRI
- Medical Research Council [G117/452] Funding Source: researchfish
- Medical Research Council [G117/452] Funding Source: Medline
The cation-independent mannose 6-phosphate receptor (CIMPR) cycles between the trans-Golgi network ( TGN) and endosomes to mediate sorting of lysosomal hydrolases. The endosome-to-TGN retrieval of the CIMPR requires the retromer complex. Genetic, biochemical and structural data support the hypothesis that the retromer can directly bind to the tail of the CIMPR, to sort the CIMPR into vesicles and tubules for retrieval to the TGN. Presently, however, no known retromer sorting motif in the tail of the CIMPR has been identified. Using CD8-reporter proteins carrying the cytoplasmic tail of the CIMPR we have systematically dissected the CIMPR tail to identify a novel, conserved aromatic-containing sorting motif that is critical for the endosome-to-TGN retrieval of the CIMPR and for the interaction with retromer and the clathrin adaptor AP-1.
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