期刊
JOURNAL OF CELL SCIENCE
卷 120, 期 14, 页码 2454-2466出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.004200
关键词
cornichon; EGFR; transport; secretion; functional conversation
类别
资金
- NCI NIH HHS [R01 CA54826] Funding Source: Medline
Cornichon proteins are structurally related transmembrane proteins that have been studied in and Drosophila and yeast. In Drosophila, Cornichon (Cni) is involved in embryo polarization by the TGF alpha-related Gurken. In yeast, the Cni-related Erv14 is required for axial budding. A cargo receptor function has been proposed for Erv14 and Cni. Four mammalian Cni-like sequences have been identified. We carried out parallel functional analyses of the human Cni ortholog CNIH and Drosophila Cni in the processing and presentation of TGF alpha family proteins. Human CNIH complements the loss of Erv14 in yeast. Human CNIH and Drosophila Cni are primarily localized in the endoplasmic reticulum and associate with immature TGF alpha family proteins. Alterations of cornichon expression result in changes in transport, processing and secretion of TGF alpha proteins. In particular, increased cornichon expression retains TGF alpha proteins in the endoplasmic reticulum, whereas cornichon is required for their transport and secretion. Thus, cornichon proteins represent a functionally conserved protein family that acts in the selective transport and maturation of TGF alpha family proteins.
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