期刊
BRAIN RESEARCH
卷 1158, 期 -, 页码 71-80出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2007.05.010
关键词
prion; sleep; EEG; stress; deprivation; hormones
资金
- NIA NIH HHS [AG04342, P01 AG004342, P01 AG004342-22S10013] Funding Source: Medline
- NIDA NIH HHS [P01 DA012444-01A1, P01 DA012444, DA12444] Funding Source: Medline
In order to gain insights on the function of the cellular prion protein (PrPc) sleep and the levels of the stress hormones corticosterone (CORT) and the adrenocorticotropic hormone (ACTH) before and after sleep deprivation (SD) were compared in two wild type (WT) mice strains and the following three PrPc transgenic lines: mice null for PrPc (mPrP(0/0)) and mice with specific and central expression of PrP in neurons (NSE-HPrP/mPrP(0/0)) or in glia cells (GFAP-HPrP/mPrP(0/0)). After SD mPrP(0/0) mice showed a larger degree of sleep fragmentation and of latency to enter rapid eye movement (REM) and non-REM sleep (NREM) than WT. During sleep recovery, the amount of NREM sleep and the slow-wave activity (SWA) were reduced in mPrP(0/0) mice. After SD, CORT and ACTH levels have distinct patterns in WT and mPrP(0/0). The NREM and SWA deficit was restored in NSE-HPrP/mPrP(0/0) mice but not in GFAP-HPrP/mPrP(0/0). Hormonal profile was only partially restored in NSE-HPrP/mPrP(0/0) mice and was similar to that of mPrP(0/0) and GFAP-HPrP/mPrP(0/0) mice. These findings demonstrate that neuronal, but not non-neuronal, PrPC is involved in sleep homeostasis and sleep continuity. They also suggest that neuronal PrPC-dependent hormonal regulation of HPA axis may contribute to the sleep homeostasis. (c) 2007 Elsevier B.V. All rights reserved.
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