期刊
JOURNAL OF NEUROSCIENCE
卷 27, 期 29, 页码 7786-7798出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1807-07.2007
关键词
cortex; electrophysiology; GABA; genetics; interneurons; transcription factor; electrophysiology
资金
- NIMH NIH HHS [R01 MH068469] Funding Source: Medline
- NINDS NIH HHS [R01 NS039007, R01NS039007] Funding Source: Medline
Inhibitory GABAergic interneurons of the mouse neocortex are a highly heterogeneous population of neurons that originate from the ventral telencephalon and migrate tangentially up into the developing cortical plate. The majority of cortical interneurons arise from a transient embryonic structure known as the medial ganglionic eminence (MGE), but how the remarkable diversity is specified in this region is not known. We have taken a genetic fate mapping strategy to elucidate the temporal origins of cortical interneuron subtypes within the MGE. We used an inducible form of Cre under the regulation of Olig2, a basic helix-loop-helix transcription factor highly expressed in neural progenitors of the MGE. We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation.
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