期刊
JOURNAL OF NEUROSCIENCE
卷 27, 期 29, 页码 7648-7653出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0395-07.2007
关键词
impairment; PP1; oligomers; A beta-peptide; Alzheimer's disease; LTP
Amyloid beta (A beta) oligomers are derived from proteolytic cleavage of amyloid precursor protein (APP) and can impair memory and hippocampal long-term potentiation (LTP) in vivo and in vitro. They are recognized as the primary neurotoxic agents in Alzheimer's disease. The mechanisms underlying such toxicity on synaptic functions are complex and not fully understood. Here, we provide the first evidence that these mechanisms involve protein phosphatase 1 (PP1). Using a novel transgenic mouse model expressing human APP with the Swedish and Arctic mutations that render A beta more prone to form oligomers (arcA beta mice), we show that the LTP impairment induced by A beta oligomers can be fully reversed by PP1 inhibition in vitro. We further demonstrate that the genetic inhibition of endogenous PP1 in vivo confers resistance to A beta oligomer-mediated toxicity and preserves LTP. Overall, these results reveal that PP1 is a key player in the mechanisms of AD pathology.
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