期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 129, 期 28, 页码 8766-8773出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja070572k
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资金
- NIGMS NIH HHS [GM 59417] Funding Source: Medline
In the presence of a chiral phosphoramidite ligand, the palladium-catalyzed diboration of allenes can be executed with high enantioselectivity. This reaction provides high levels of selectivity with a range of aromatic and aliphatic allene substrates. Isotopic-labeling experiments, stereodifferentiating reactions, kinetic analysis, and computational experiments suggest that the catalytic cycle proceeds by a mechanism involving rate-determining oxidative addition of the diboron to Pd followed by transfer of both boron groups to the unsaturated substrate. This transfer reaction most likely occurs by coordination and insertion of the more accessible terminal alkene of the allene substrate, by a mechanism that directly provides the eta(3) pi-allyl complex in a stereospecific, concerted fashion.
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