期刊
ANALYTICAL BIOCHEMISTRY
卷 415, 期 2, 页码 203-205出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2011.04.032
关键词
-
资金
- Foundation for Research Support from the State of Rio de Janeiro (FAPERJ)
Cell death by apoptosis triggers the engagement of a conserved intracellular machinery of execution, involving mainly the activation of the caspase family of cysteine proteases. Caspase-3 is a common effector of most of the apoptotic pathways and is able to cleave several target proteins whose degradation will contribute to the execution phase of the cell demise program. Here we present a modification of the Western blot protocol to improve sensitivity of caspase-3 detection, providing a valuable tool to access its activation in biological specimens. (C) 2011 Elsevier Inc. All rights reserved.
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