期刊
SCIENCE
卷 317, 期 5836, 页码 372-376出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1139740
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [R01 CA088060] Funding Source: Medline
Primary cilia are essential for transduction of the Hedgehog (Hh) signal in mammals. We investigated the role of primary cilia in regulation of Patched1 (Ptc1), the receptor for Sonic Hedgehog (Shh). Ptc1 localized to cilia and inhibited Smoothened (Smo) by preventing its accumulation within cilia. When Shh bound to Ptc1, Ptc1 left the cilia, leading to accumulation of Smo and activation of signaling. Thus, primary cilia sense Shh and transduce signals that play critical roles in development, carcinogenesis, and stem cell function.
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