期刊
FEBS LETTERS
卷 581, 期 18, 页码 3341-3344出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.06.020
关键词
lipoprotein; hydrogenase; tat pathway; signal peptidase II; Desulfovibrio
Desulfovibrio vulgaris Hildenborough has a membrane-bound [NiFeSe] hydrogenase whose mode of membrane association was unknown since it is constituted by two hydrophilic subunits. This work shows that this hydrogenase is a bacterial lipoprotein bound to the membrane by lipidic groups found at the N-terminus of the large subunit, which is unusual since it is missing the typical lipoprotein signal peptide. Nevertheless, the large subunit has a conserved four residue lipobox and its synthesis is sensitive to the signal peptidase II inhibitor globomycin. The D. vulgaris [NiFeSel hydrogenase is the first example of a bacterial lipoprotein translocated through the Tat pathway. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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