期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 104, 期 30, 页码 12554-12559出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0705087104
关键词
dual-pair recording; in vitro; patch clamp; voltage-sensitive dye imaging; Provigil
资金
- NINDS NIH HHS [P01 NS013742, NS13742] Funding Source: Medline
Modafinil (Provigil, Modiodal), an antinarcoleptic and mood-enhancing drug, is shown here to sharpen thalamocortical activity and to increase electrical coupling between cortical interneurons and between nerve cells in the inferior olivary nucleus. After irreversible pharmacological block of connexin permeability (i.e., by using either 18 beta-glycyrrhetinic derivatives or mefloquine), modafinil restored electrotonic coupling within 30 min. It was further established that this restoration is implemented through a Ca2+/calmodulin protein kinase II-dependent step.
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