期刊
FEBS LETTERS
卷 581, 期 18, 页码 3550-3556出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.06.063
关键词
CD248; stromal cells; tissue repair; Salmonella
资金
- MRC [G116/131, G0401620] Funding Source: UKRI
- Medical Research Council [G0401620, G116/131] Funding Source: Medline
- Breast Cancer Now [BREAST CANCER NOW RESEARCH CENTRE] Funding Source: Medline
- Medical Research Council [G0401620, G116/131] Funding Source: researchfish
Studies of stromal cell populations in lymphoid tissue (LT) have been hampered by a lack of selective markers. Here, we show that CD248 (Endosialin/TEMI) is a stromal marker that is differentially expressed on fibroblasts and pericytes in the thymus, lymph node and spleen. Expression is high during LT development but largely disappears in the adult. CD248 is re-expressed in a Salmonella-induced model of splenic enlargement; peak expression corresponding to the peak of splenic enlargement. These results suggest that CD248 expression helps define a subset of LT stromal cells which play a role in remodelling during tissue development, infection and repair. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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