期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 359, 期 2, 页码 311-316出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2007.05.098
关键词
chondrocyte; mesenchymal stem cells; high density culture; cartilage repair; mechanical property; tissue regeneration; nanoindentation
资金
- NIDCR NIH HHS [R01 DE13194, R01 DE014526-05, R01 DE013194, R01 DE14526, R01 DE014526] Funding Source: Medline
Cartilage is an avascular tissue with only a limited potential to heal and chondrocytes in vitro have poor proliferative capacity. Recently, adipose-derived stromal cells (ASC) have demonstrated a great potential for application to tissue engineering due to their ability to differentiate into cartilage, bone, and fat. In this study, we have utilized a high density three-dimensional (3D) micromass model system of early chondrogenesis with ASC. The material properties of these micromasses showed a significant increase in dynamic and static elastic modulus during the early chondrogenic differentiation process. These data suggest that the 3D micromass culture system represents an in vitro model of early chondrogenesis with dynamic cell signaling interactions associated with the mechanical properties of chondrocyte differentiation. (c) 2007 Elsevier Inc. All rights reserved.
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