期刊
SCIENCE
卷 317, 期 5837, 页码 496-499出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1145229
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资金
- National Research Foundation of Korea [2006-214-C00044] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- NIGMS NIH HHS [R01 GM073932] Funding Source: Medline
Traditionally, transition metal-catalyzed enantioselective transformations rely on chiral ligands tightly bound to the metal to induce asymmetric product distributions. Here we report high enantioselectivities conferred by a chiral counterion in a metal-catalyzed reaction. Two different transformations catalyzed by cationic gold( I) complexes generated products in 90 to 99% enantiomeric excess with the use of chiral binaphthol-derived phosphate anions. Furthermore, we show that the chiral counterion can be combined additively with chiral ligands to enable an asymmetric transformation that cannot be achieved by either method alone. This concept of relaying chiral information via an ion pair should be applicable to a vast number of metal-mediated processes.
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