期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 163, 期 2, 页码 208-212出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2007.03.004
关键词
hemodynamic response function; fMRI; aging; HIV; neuropsychological impairment; BOLD response; cognitive impairment
资金
- NIA NIH HHS [AG21431] Funding Source: Medline
- NIMH NIH HHS [K-23 MH64678] Funding Source: Medline
Functional magnetic resonance imaging (fMRI) has revealed much about altered CNS function in HIV/AIDS. In this study, we compared the blood oxygen level dependent hemodynamic response function (BOLD HRF) signal in HIV/AIDS and control subjects as a necessary pre-condition for fMRI studies of higher level cognitive function. Using event-related fMRI, subjects performed a simple sensory-motor activity allowing the measurement of the BOLD HRF in the precentral gyrus. There were no significant differences in the HRF when viewed as a function of age, hemisphere, or HIV serostatus. However, significant results were found after dividing the subjects by NIMH impairment classifications. There were 16 control subjects, 19 Normal/Asymptomatic Neuropsychological Impairment (ANT), and 11 Minor Neurocognitive Disorder (MNCD)/HIV-Associated Dementia (HAD) subjects. The HRF of MNCD/HAD subjects did not return to baseline after 16 s, suggesting subtle alterations in neuronal function, which may affect event-related fMRI studies. (c) 2007 Elsevier B.V. All rights reserved.
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