期刊
ANALYTICA CHIMICA ACTA
卷 597, 期 1, 页码 6-11出版社
ELSEVIER
DOI: 10.1016/j.aca.2007.06.040
关键词
molecularly imprinted polymer; carbamazepine; solid-phase extraction; urine samples; wastewater
A molecularly imprinted polymer (MIP) designed to enable the selective extraction of carbamazepine (CBZ) from effluent wastewater and urine samples has been synthesised using a non-covalent molecular imprinting approach. The MIP was evaluated chromatographically in the first instance and its affinity for CBZ also confirmed by solid-phase extraction (SPE). The optimal conditions for SPE consisted of conditioning of the cartridge using acidified water purified from a Milli-Q system, loading of the sample under basic aqueous conditions, clean-up using acetonitrile and elution with methanol. The attractive molecular recognition properties of the MIP gave rise to good CBZ recoveries (80%) when 100 mL of effluent water spiked with 1 mu g L-1 was percolated through the polymer. For urine samples, 2 mL samples spiked with 2.5 mu g L-1 CBZ were extracted with a recovery of 65%. For urine, the linear range was 0.05-24 mg L-1, the limit of detection was 25 mu g L-1 and precision, expressed as relative standard deviation at 0.5 mg L-1 (n = 3), was 3.1% and 12.6% for repeatability and reproducibility between days, respectively. (c) 2007 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据