期刊
FEBS LETTERS
卷 581, 期 19, 页码 3716-3722出版社
WILEY
DOI: 10.1016/j.febslet.2007.04.082
关键词
heat shock proteins; T cells; immunologic tolerance; cell stress; adjuvant arthritis; immuno-therapy
T cell responses to heat shock proteins (HSP) have disease suppressive activities through production of anti-inflammatory cytokines in patients and in models of inflammatory diseases. There is evidence that the anti-inflammatory activity of HSP-specific T cells depends on their recognition of endogenous HSP epitopes as expressed by stressed cells at sites of inflammation. Previously, we have demonstrated that such T cells can be induced by conserved sequences of microbial HSP. Now we propose that drug induced up-regulation of endogenous HSP can contribute to anti-inflammatory T cell regulation. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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