期刊
ANALYTICAL BIOCHEMISTRY
卷 391, 期 2, 页码 163-165出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2009.05.011
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资金
- CNRS [UMR 8619]
- European Community [LSHM-CT-2004-512138]
The WecA transferase is an integral membrane protein and a member of the polyprenyl phosphate N-acetylhexosamine-1-phosphate transferase superfamily. It initiates the biosynthesis of various bacterial cell envelope components such as the lipopolysaccharide O-antigen. We report on the first large-scale enzymatic synthesis, Purification, and characterization of the undecaprenyl-pyrophosphoryl-N-acetylglucosa mine product of the WecA transferase. This is an essential lipid intermediate for the biosynthesis of various bacterial cell envelope components. Its availability in a pure form will allow the biochemical and structural characterization of the various enzymes requiring it as a substrate for the synthesis of cell wall polymers. (C) 2009 Elsevier Inc. All rights reserved.
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