期刊
STEM CELLS
卷 25, 期 8, 页码 1881-1887出版社
WILEY
DOI: 10.1634/stemcells.2007-0163
关键词
bone marrow cells; malignancy; differentiation; plasticity; hematopoietic stem cell; bone marrow transplantation
资金
- NIDDK NIH HHS [K08 DK067359] Funding Source: Medline
Bone marrow cells have the capacity to contribute to distant organs. We show that marrow also contributes to epithelial neoplasias of the small bowel, colon, and lung, but not the skin. In particular, epithelial neoplasias found in patients after hematopoietic cell transplantations demonstrate that human marrow incorporates into neoplasias by adopting the phenotype of the surrounding neoplastic environment. To more rigorously evaluate marrow contribution to epithelial cancer, we employed mouse models of intestinal and lung neoplasias, which revealed specifically that the hematopoietic stem cell and its progeny incorporate within cancer. Furthermore, this marrow involvement in epithelial cancer does not appear to occur by induction of stable fusion. Whereas previous claims have been made that marrow can serve as a direct source of epithelial neoplasia, our results indicate a more cautionary note, that marrow contributes to cancer as a means of developmental mimicry.
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