期刊
JOURNAL OF VIROLOGY
卷 81, 期 15, 页码 8346-8351出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00465-07
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资金
- NIAID NIH HHS [2R01-AI-46995, R01 AI046995, P30 AI027757, AI-64060, R01 AI064060-03, R01 AI064060] Funding Source: Medline
- PHS HHS [N01-A1-15422] Funding Source: Medline
HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type I (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients was delayed by the compensatory mutation S165N within the same epitope. These data may help explain the observed association between HLA-B*5703 and long-term control of viremia.
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