期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 82, 期 2, 页码 265-271出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.0107021
关键词
MD-1; endogenous ligand; counter-regulation
资金
- NIAID NIH HHS [AI057992, AI063183, T32AI055406] Funding Source: Medline
As all immune responses have potential for damaging the host, tight regulation of such responses-in amplitude, space, time and character -is essential for maintaining health and homeostasis. It was thus inevitable that the initial wave of papers on the role of Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs) in activating innate and adaptive immune responses would be followed by a second wave of reports focusing on the mechanisms responsible for restraining and modulating signaling by these receptors. This overview outlines current knowledge and controversies about the immunobiology of the RP105/MD-1 complex, a modulator of the most robustly signaling TLR, TLR4.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据