期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 410, 期 25, 页码 6387-6409出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-018-1252-y
关键词
Lipidomics; Mass spectrometry; Electrospray ionization; MALDI; Collision induced dissociation; Lipid
资金
- US Public Health Service Grants [P41-GM103422, P60-DK-20579, P30-DK56341, 4R33HL120760-03, R01AI130454]
Over the past decade, mass spectrometry (MS)-based shotgun lipidomics has emerged as a powerful tool for quantitative and qualitative analysis of the complex lipids in the biological system. The aim of this critical review is to give the interested reader a concise overview of the current state of the technology, focused on lipidomic analysis by mass spectrometry. The pros and cons, and pitfalls associated with each available shotgun lipidomics method are discussed; and the new strategies for improving the current methods are described. A list of important papers and reviews that are sufficient rather than comprehensive, covering all the aspects of lipidomics including the workflow, methodology, and fundamentals is also compiled for readers to follow.
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