期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
卷 143A, 期 15, 页码 1726-1732出版社
WILEY
DOI: 10.1002/ajmg.a.31812
关键词
neural tube defects; 5,10-methylenetetrahydrofolate reductase; variant 677C > T; meta-analysis; Irish population
There are several studies that have found a positive association between neural tube defects (NTDs) and the common mutation 677C > T of 5, 10-methylenetetrahydrofolate reductase (MTHFR), and others that have not found Such an association. We updated the meta-analyses of the published data about NTDs and MTHFR 677C > T variant from January 1994 to October 2005 identifying 170 potentially relevant studies. After applying pertinent exclusion criteria, 37 different populations from 32 studies were included in the meta-analysis, with a total of 3,530 cases and 6,296 controls. Further we stratified the data according to geographical region and ethnicity, and produced two separated meta-analyses for non-Latin European and Latin European descent populations. The general (odds ratio 1.41; 95% confidence interval 1.24-1.59), and the non-Latin European meta-analyses (1.62; 1.38-1.90) indicate an association of TT genotype and NTDs; no association was demonstrated for Latin European populations (1.16; 0.95-1.43). The examination of non-Latin European studies revealed that the association of TT genotype with NTD has only been proven for Irish populations, both by case-control studies, and by family-based tests, such as the allele transmission disequilibrium test (TDT). (c) 2007 Wiley-Liss, Inc.
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