期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 42, 期 8, 页码 1137-1143出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2007.01.012
关键词
oxazolidinone; linezolid; antibacterial agents; gram-positive organisms
A new series of oxazolidinones containing triazolyl group has been synthesized and tested for in vitro antibacterial activity by MIC determination against a panel of resistant and susceptible Gram-positive organisms. Most of the analogs in this series displayed activity superior to linezolid and vancomycin in vitro. Further, in vivo efficacies of the selected oxazolidinones were also disclosed herein. (c) 2007 Elsevier Masson SAS. All rights reserved.
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