期刊
NEUROLOGIC CLINICS
卷 25, 期 3, 页码 741-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2007.03.001
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资金
- NIA NIH HHS [R01-AG15866, P50-AG16574, P50 AG016574, R01 AG015866] Funding Source: Medline
- NINDS NIH HHS [P50-NS40256, P50 NS040256] Funding Source: Medline
The advent of new immunostains have improved the ability to detect limbic and cortical Lewy bodies, and it is evident that dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen symptoms and those that may improve them. Neurocognitive patterns, psychiatric features, extrapyramidal signs, and sleep disturbance are helpful in differentiating DLB from AD early in the disease course. Differences in the severity of cholinergic depletion and type/ distribution of neuropathology contribute to these clinical differences.
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