期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 64, 期 15, 页码 1930-1944出版社
BIRKHAUSER VERLAG AG
DOI: 10.1007/s00018-007-7045-7
关键词
glycogen synthase kinase-3 (GSK-3); mechanism of action; inhibitors; signalling; disease; kinase; regulation
资金
- Biotechnology and Biological Sciences Research Council [BB/D00117X/1] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/D00117X/1] Funding Source: researchfish
- BBSRC [BB/D00117X/1] Funding Source: UKRI
The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified as a key regulator of insulin-dependent glycogen synthesis. GSK-3 was subsequently shown to function in a wide range of cellular processes including differentiation, growth, motility and apoptosis. Aberrant regulation of GSK-3 has been implicated in a range of human pathologies including Alzheimer's disease, non-insulin dependent diabetes mellitus ( NIDDM) and cancer. As a consequence, the regulation of GSK-3 and the therapeutic potential of GSK-3 inhibitors have become key areas of investigation. This review will focus on the mechanisms of GSK-3 regulation, with emphasis on modulation by upstream signals, control of substrate specificity and GSK-3 localisation. The details of these mechanisms will be discussed in the context of specific signalling pathways.
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