期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 22, 期 8, 页码 1245-1259出版社
WILEY
DOI: 10.1359/JBMR.070420
关键词
Pten; growth plate; conditional knockout; bone overgrowth; Col2aCre
To study the role of the Pten tumor suppressor in skeletogenesis, we generated mice lacking this key phosphatidylinositol 3'-kinase pathway regulator in their osteo-chondroprogenitors. A phenotype of growth plate dysfunction and skeletal overgrowth was observed.
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