期刊
JOURNAL OF MEDICAL PRIMATOLOGY
卷 36, 期 4-5, 页码 266-275出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1600-0684.2007.00244.x
关键词
contraception; inflammation; live-attenuated; vaccine; progesterone; T-cell activation
资金
- NCRR NIH HHS [U51RR00169, P51 RR000169] Funding Source: Medline
- NIAID NIH HHS [P01 AI066314-030001, R01 AI094620, P01 AI066314-04S1, P01 AI066314-01, P01 AI066314-020001, P01 AI066314, R01 AI44480, P01 AI066314-03, P01 AI066314-049001, P01 AI066314-039001, P01 AI066314-029001, P01 AI066314-02, P01 AI066314-019001, P01 AI066314-04, P01 AI066314-017490, P01 AI066314-040001, P01 AI066314-010001] Funding Source: Medline
Background Progesterone administration prior to intravaginal challenge with pathogenic SIVmac239 decreases the protective efficacy of live attenuated vaccines in rhesus macaques. Methods To determine if progesterone alters the efficacy of live attenuated vaccines through local or systemic effects, seven male rhesus macaques were immunized with SHIV89.6 and then challenged intravenously with SIVmac239. Three of these animals were treated with Depo-Provera 31) days prior to the SIV challenge. Results The SHIV animals had significantly lower plasma viral RNA levels than the unimmunized control monkeys, but the Depo-Provera treated, SHIV-immunized animals did not. Despite the lack of protection, the Depo-Provera SHIV animals had strong SIV specific T-cell responses. However, altered patterns of NK frequency and CD38 T-cell expression prior to SIV challenge were observed in Depo-Provera SHIV animals. Conclusions Depo-Provera eliminates live-attenuated lentivirus vaccine efficacy in male rhesus monkeys through systemic effects on antiviral immunity and/or viral replication.
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