期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1771, 期 8, 页码 983-990出版社
ELSEVIER
DOI: 10.1016/j.bbalip.2007.02.006
关键词
PPAR; metabolic syndrome; pharmacology; skeletal muscle
The prevalence of metabolic disturbances, collectively known as metabolic syndrome, has reached an epidemic proportion in industrialized countries. Lifestyle interventions and pharmacological treatments of such pathologies are only partially efficient and new therapeutic approaches are urgently needed. This review focuses on the recent findings describing the regulatory functions of peroxisome proliferator-activated receptor beta (PPAR) on lipid metabolism in several tissues and on the implications of such findings on the therapeutic usefulness of PPAR beta agonists in the treatment of particular features of the metabolic syndrome, such as insulin resistance, obesity, dyslipidemia and cardiac dysfunctions. (c) 2007 Elsevier B.V All rights reserved.
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