期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 35, 期 -, 页码 686-688出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0350686
关键词
astrocyte; central nervous system; glial cell; metalloproteinase; monocyte; tuberculosis (TB)
资金
- Medical Research Council [G0500385] Funding Source: researchfish
- MRC [G0500385] Funding Source: UKRI
- Medical Research Council [G0500385] Funding Source: Medline
The CNS (central nervous system) has a unique pattern of immune response to infection. TB (tuberculosis) of the CNS is devastating with widespread tissue destruction. In TB, astrocyte-leucocyte interactions are key in regulating MMP (matrix metalloproteinase) activity and are regulated by complex signalling pathways. A synergistic interaction between interferon gamma and monocyte-derived mediators drives high-level astrocyte MMP-9 secretion; this and other networking effects are inhibited by steroids. Better understanding of regulatory mechanisms may identify potential switch points that could be future therapeutic targets.
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