期刊
NATURE GENETICS
卷 39, 期 8, 页码 954-956出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng2098
关键词
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资金
- NCI NIH HHS [R01 CA054281, P01 CA17054, R01 CA060987, CA60987, P01 CA017054, CA72520, CA63464, U01 CA063464, R37 CA054281, R01 CA063464-09S1, R01 CA072520, R01 CA063464, CA54281] Funding Source: Medline
Variants on chromosome 8q24 contribute risk for prostate cancer; here, we tested whether they also modulate risk for colorectal cancer. We studied 1,807 affected individuals and 5,511 controls and found that one variant, rs6983267, is also significantly associated with colorectal cancer ( odds ratio = 1.22; P = 4.4 x 10(-6)) and that the apportionment of risk among the variants differs significantly between the two cancers. Comprehensive testing in the region uncovered variants capturing significant additional risk. Our results show that variants at 8q24 have different effects on cancer development that depend on the tissue type.
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