期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 26, 期 2, 页码 427-431出版社
JOHN WILEY & SONS INC
DOI: 10.1002/jmri.20985
关键词
MRS; spectroscopic imaging; metabolite quantification; short TE; 3 Tesla
Purpose: To compare the spectral quality of short echo time (TE) MR spectroscopic imaging (MRSI, TE = 30 msec) with long-TE MRSI (TE 144 msec) at 3 Tesla in normal brain and tumor tissue. Materials and Methods: Spectroscopic imaging (chemical-shift imaging (CSI)) data of 32 patients with histopathological confirmed brain lesions were acquired at 3 Tesla (3T) using TEs of 30 msec and 144 msec. Tumor-relevant metabolites (trimethylamine (TMA), creatine compounds (tCr), and N-acetylated compounds (tNAA)) were analyzed with LCModel software, which applies prior knowledge by performing a frequency domain fit using a linear combination of model spectra. Results: Short-TE spectra provided up to twice the signal-to-noise ratio (SNR) compared to TE = 144 msec. The estimated fitting error was improved up to 30% for TMA and tCr, but was slightly reduced (10%) for tNAA. Quantification in terms of absolute concentrations was consistent at both TEs. Conclusion: Since other metabolites observable at TE < 30 msec may be of diagnostic relevance, short-TE MRSI should be the preferred method at 3T for the evaluation of focal lesions in brain tissue; however, TE = 144 msec can serve as an option for MRS in regions with potential baseline problems.
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