期刊
JOURNAL OF CARDIAC FAILURE
卷 13, 期 6, 页码 462-469出版社
CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
DOI: 10.1016/j.cardfail.2007.03.004
关键词
prognosis; ventilatory efficiency; expired gas analysis
资金
- RRD VA [IK6 RX002477] Funding Source: Medline
Background: Ventilatory efficiency, commonly assessed by the minute ventilation (VE)-carbon dioxide production (VCO2) slope, has proven to be a strong prognostic marker in the heart failure (HE) population. Recently, the oxygen uptake efficiency slope (OUES) has demonstrated prognostic value, but additional comparisons to established cardiopulmonary exercise test (CPET) variables are required. Methods and Results: A total of 341 subjects were diagnosed with HF participated in this analysis. The VE/VCO2, slope and the OUES were calculated using 50% (VE/VCO2 slope(50) or OUES50) and 100% (VE/VCO2, slope(100) or OUES100) of the exercise data. Peak oxygen consumption (VO2) was also determined. There were 47 major cardiac-related events during the 3-year tracking period. Receiver operating characteristic (ROC) curve analysis demonstrated the classification schemes for both VE/VCO2 slope and OUES calculations as well as peak VO2 were statistically significant (all areas under the ROC curve: >= 0.74, P <.001). Area under the ROC curve for the VE/VCO2 slope(100) was, however, significantly greater than OUES50, OUES100, and peak VO2 (P <.05). Conclusions: Although the OUES was a significant predictor of mortality, the VE/VCO2 Slope maintained optimal prognostic value. An elevated VE/VCO2 slope may be the single best indicator of increased risk for adverse events.
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