期刊
JOURNAL OF NEURAL TRANSMISSION
卷 114, 期 8, 页码 1065-1068出版社
SPRINGER WIEN
DOI: 10.1007/s00702-007-0705-9
关键词
5-HT1A; BDNF; polymorphism; major depression; treatment-resistant; electroconvulsive therapy
Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. We attempt to show that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression. The sample consists of 119 patients with treatment-resistant MDD and 392 controls. 5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.
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