期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 11, 期 8, 页码 1005-1009出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.11.8.1005
关键词
autoimmune disease; cancer; inflammation; TIM-3; tolerance
T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) was the first, and is presently the only, surface molecule that can specifically identify T(H)1 cells in both mice and humans. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear.
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